Setting the standard in Brillouin Microscopy

Highest performance combined
with unique user experience

Discoverer™ Brillouin Microscope: perfect for living cells, organoids, tissues, and small organisms

The fully automated Discoverer™ is the ideal tool to measure mechanical properties of biological samples in volume by optical spectroscopy.

The Discoverer™ system features a 780 nm laser with low phototoxicity that minimizes damage to samples during prolonged studies. Users can measure mechanical properties in 3D in a passive way, without any mechanical contact. This non-invasive optical measurement of mechanics is a significant benefit for living samples.

The Discoverer™ from Cellsense: combining the latest Brillouin technology with superb flexibility and ease-of-use

The Discoverer™ is designed for maximum mechanical and thermal stability, compatible with both inverted and upright microscopes for long-term experiments on living samples. It features the latest Brillouin technology, including a multi-stage interferometric spectrum detector, optimized beam path, high-quality optical components with perfected coatings, and innovative automation features. The Discoverer™ is a masterpiece of engineering. Its revolutionary software design enables users to obtain quick results without being experts. It offers a wide range of accessories, modes, and features, providing unparalleled flexibility for any application.

The Discoverer™: Designed for multimodal imaging

The Discoverer™ system is a newly developed add-on for motorized inverted or upright research microscopes. It is compatible with major microscope brands, including Zeiss, Leica, Olympus/Evident, and Nikon. The installation is quick and straightforward, taking only minutes to complete. The OptiBridge™ module from CellSense connects to a side port of the microscope body, seamlessly integrating the system. The motorized microscope body is fully utilized and controlled via the Discoverer™ software, enhancing the light microscope’s capabilities with a mechanical imaging channel for true multimodal imaging. Developed by experienced professionals in mechanobiology instrumentation, the Discoverer™ is ready to use.

Compatible with major microscope brands

Easy operation is key

The Discoverer™ microscope is designed with the user in mind. Its integrated design eliminates the need for manual adjustments of optical or mechanical components.

Simply mount the sample on the sample stage as usual and control the microscope hardware through the intuitive software user interface. Time-consuming steps are minimized to save the user’s time.

New workflow-based software design simplifies your work

Our intuitive software interface streamlines complex measurement tasks, making it accessible to users of all expertise levels. The workflow structure and task-based desktops organize all necessary information for different steps, guiding users naturally through the setup and acquisition process. This straightforward approach enables even those with minimal Brillouin experience to quickly achieve important results. Experienced light microscopy researchers will appreciate the efficient experiment selection, predefined modes, favorites, and quick navigation. The revolutionary FlowPlanner™ software feature, with its step-by-step workflow structure, provides a logical progression for essential tasks. It guides users through experiment setup with intelligent help and status feedback for alignment and setup. This makes it simple, even for those with minimal experience, to confidently generate high-quality data in a short time frame.

Intelligent stiffness mapping of large sample areas with new tiling functionality

Our intuitive software interface streamlines complex measurement tasks, making it accessible to users of all expertise levels. The workflow structure and task-based desktops organize all necessary information for different steps, guiding users naturally through the setup and acquisition process. This straightforward approach enables even those with minimal Brillouin experience to quickly achieve important results. Experienced light microscopy researchers will appreciate the efficient experiment selection, predefined modes, favorites, and quick navigation. The revolutionary FlowPlanner™ software feature, with its step-by-step workflow structure, provides a logical progression for essential tasks. It guides users through experiment setup with intelligent help and status feedback for alignment and setup. This makes it simple, even for those with minimal experience, to confidently generate high-quality data in a short time frame.

Superior data correlation with the new PerfectOverlay™ feature

The advanced PerfectOverlay™ feature enables easy optically guided navigation to define areas of interest directly in brightfield or fluorescence images. Smart integration maximizes the benefits of simultaneous Brillouin and optical measurements. Our calibration algorithms, visualization routines, and usability have all been optimized to offer the most user-friendly functionality available today.

Features and benefits

Non-invasive Imaging: Measures mechanical properties of cells and tissues without damaging the sample.

Label-Free Technology: Provides clean and unaltered measurements without the need for dyes or markers.

Easy Integration: Compatible with both upright and inverted microscopes, enabling easy setup and use.

Low Phototoxicity: Features a 780 nm laser that minimizes damage to samples during prolonged studies.

Real-Time Data: Allows researchers to start obtaining mechanical data from live samples immediately.

High-Resolution Detection: Equipped with a multi-stage interferometric spectrum detector for detailed mechanical analysis.

User-Friendly Software: Intuitive software interface simplifies complex measurement tasks, making it accessible to users at all levels of expertise.

Quantitative Analysis: Delivers precise, reproducible results that enhance scientific studies.

Versatility: Suitable for a wide range of applications from biomedical research to material science.

Expert Design: Developed by seasoned professionals with extensive experience in mechanobiology instrumentation.

Specifications for the Discoverer™ Brillouin Microscope

Basic configuration

  • Laser module
  • Spectrometer module
  • OptiBridge™ module
  • PC and software

System specifications

  • Integrated closed-box system, with highest mechanical and thermal stability  
  • Advanced fiber coupling to existing inverted or upright light microscopes 
  • Near IR laser excitation with 780nm for lowest phototoxicity and uncompromised fluorescence  
  • Spectral resolution <1pm 
  • Highest detector sensitivity for fastest signal capture 
  • Transmission illumination with standard condensers for precise brightfield, DIC and phase contrast 
  • Fully automated system setup and calibration 
  • Dimensions of laser module and spectrometer module both stackable with 110x65x24cm³ 
  • Dimension OptiBridge™ with 42x40x15cm³ 

Optical configurations

  • Fits on inverted motorized microscopes from Zeiss (Axio Observer, Axio Vert 200)
    • Olympus/Evident (IX line)
    • Nikon (TE 2000, Ti line)
    • Leica (DMi line)
  • Brillouin simultaneously with optical microscopy
    • Fully simultaneous operation with optical phase contrast and DIC using standard condensers
  • Combine Brillouin with advanced commercial confocal microscopes and all advanced fluorescence optical techniques
  • For high-NA upright fluorescence optics combined with Brillouin on tissues samples
    • Supports upright research microscopes such as Zeiss Axio Imager and Axioscope, Olympus/Evident BX51/53, Leica DM 4000/5000

Stages and sample holders

  • Motorized stages are available for all major inverted optical microscope manufacturers such as Zeiss, Nikon, Olympus/Evident and Leica
  • Holders for Petri dishes, coverslips, microscope slides or well plates are available

New workflow-based Discoverer™ software

  • Revolutionary user experience with the new interface design
  • True multi-user platform, perfect for imaging facilities
  • New PerfectOverlay™ for combined optical and Brillouin or other information
  • MultiMap™ for multiple area mapping
  • FlowPlanner™ for designing a specific measurement workflow
  • Powerful Data Processing (DP) with full functionality for data export, fitting, filtering, edge detection, 3D rendering, and cross section, etc.
  • Powerful batch processing of images including and other analyses

Standard operating modes

  • Optical imaging modes
    • Brightfield imaging
    • Basic wide-field fluorescence
  • Brillouin operation
    • Brillouin mapping with Brillouin shift and linewidth
    • Advanced stiffness and viscosity mapping
    • PerfectOverlay™ for combining Brillouin and other optical images

Optional modes and accessories

  • FlowControl™ feature for remote experiment control
  • Wellplate mapping function
  • Epi-Fluorescence import function
  • Environmental control options
  • Additional XY or Z sample movement stages available